Vaccine composition energized by adjuvant

The invention relates to an adjuvant energized vaccine composition, which comprises a first component and a second component which are independently packaged, the first component comprises an antigenic substance, the second component is an energizing adjuvant, the energizing adjuvant comprises an oi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIU JUAN, YUAN CHUXIAO, HONG KUNXUE, YAO WENRONG, BAN JINGYANG, LIU YONG, WU SHUANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an adjuvant energized vaccine composition, which comprises a first component and a second component which are independently packaged, the first component comprises an antigenic substance, the second component is an energizing adjuvant, the energizing adjuvant comprises an oil-in-water emulsion adjuvant, and the oil-in-water emulsion adjuvant comprises squalene, alpha-tocopherol and Tween 80. When the vaccine composition is prepared, the two components do not need to be prepared into a finished product preparation, the two components can be independently packaged, the safety is high, the stability is good, and meanwhile the technical effects of effectively improving immune response and rapidly stimulating antibody generation can be achieved. 本发明涉及一种佐剂赋能的疫苗组合物,其包含独立包装的第一组分和第二组分,所述第一组分包含抗原性物质,所述第二组分为赋能佐剂,所述赋能佐剂包含水包油乳剂佐剂,所述水包油乳剂佐剂包含角鲨烯、α-生育酚和吐温80。本发明的疫苗组合物在制备时不需要将两种组分配制为成品制剂,两种组分可以独立包装,安全性高,稳定性好,同时可以达到有效改善免疫应答,快速刺激抗体产生的技术效果。