Fatty acid complex of coronavirus spike protein and application thereof

The present invention relates to isolated complexes of coronavirus spike proteins and fragments or mutants thereof, the fragments or mutants thereof containing at least receptor binding domains of said coronavirus spike proteins, with linoleic acid or derivatives or salts or mimetics of linoleic acid. A further subject of the invention relates to a method for producing the composites according to the invention. Further aspects of the invention are in vitro methods for identifying molecules having therapeutic potential for diseases caused by coronavirus. Further aspects of the invention are therapies for treating coronavirus infections by administering linoleic acid or a derivative, salt or mimetics thereof to a subject in need thereof, as well as diagnostics for detecting coronavirus infections. 本发明涉及冠状病毒刺突蛋白及其片段或突变体与亚油酸或亚油酸的衍生物或盐或模拟物的分离复合物，其中，其片段或突变体至少含有所述冠状病毒刺突蛋白的受体结合结构域。本发明的进一步主题涉及生产本发明复合物的方法。本发明的进一步方面是用于鉴定对冠状病毒引起的疾病具有治疗潜力的分子的体外方法。本发明的进一步方面是通过向有此需要的受试者施用亚油酸或其衍生物、盐或模拟物来治疗冠状病毒感染的疗法，以及检测冠状病毒感染的诊断法。