Siglec-15 ligand multifunctional molecular probe and application

The invention belongs to the technical field of nuclear medicine and molecular imaging, and discloses a Siglec-15 ligand multifunctional molecular probe and application, the Siglec-15 ligand multifunctional molecular probe is an anti-Siglec-15 monoclonal antibody molecular probe double-labeled by qu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YANG HUI, PAN TINGTING, ZHOU SI, GAO MENGNA, LI WENLIANG, HE YONGQIANG, ZHAO CHANG, LI NING, DU SHENZHEN
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention belongs to the technical field of nuclear medicine and molecular imaging, and discloses a Siglec-15 ligand multifunctional molecular probe and application, the Siglec-15 ligand multifunctional molecular probe is an anti-Siglec-15 monoclonal antibody molecular probe double-labeled by quantum dots QDs and CY5, and can be used for Siglec-15 in-vitro serology and in-vivo imaging detection. The probe has the advantages of easily available raw materials, low cost, simple marking method, mild reaction conditions, stable product, convenience in storage and transportation and the like in the aspect of synthesis, and is convenient to popularize and popularize. In the aspect of in-vitro serological detection, an immunochromatography test strip can be established, and the Siglec-15 expression condition of a body can be sensitively and quickly detected; in the aspect of in-vivo imaging, the polypeptide has good pharmacokinetics and excellent Siglec-15 targeting property, and can noninvasively and dynamically