Rapid screening method for nebivolol and imidapril

The invention provides a method for rapidly screening nebivolol and imidapril, which comprises the following steps: establishing an ultra-high performance liquid-ultraviolet detector (UPLC-DAD) method, and carrying out preliminary screening and quantitative detection on nebivolol and imidapril in he...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CHEN WEI, ZHAO QI, ZHANG CHAO, JIA CHANGPING
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention provides a method for rapidly screening nebivolol and imidapril, which comprises the following steps: establishing an ultra-high performance liquid-ultraviolet detector (UPLC-DAD) method, and carrying out preliminary screening and quantitative detection on nebivolol and imidapril in health-care food and Chinese patent medicine for assisting in reducing blood pressure through retention time and ultraviolet spectrum information. The positive result is further confirmed by adopting ultra-high performance liquid chromatography tandem time-of-flight mass spectrometry. Compared with a traditional high performance liquid chromatography (HPLC) method, the method disclosed by the invention is shorter in time, lower in detection limit, capable of saving a mobile phase and more environmentally friendly, and is clearer and clearer than a mass spectrum method for primary screening. At present, the device is used in daily inspection work, especially in emergency detection for handling public security cases, t