Rapid screening method for nebivolol and imidapril
The invention provides a method for rapidly screening nebivolol and imidapril, which comprises the following steps: establishing an ultra-high performance liquid-ultraviolet detector (UPLC-DAD) method, and carrying out preliminary screening and quantitative detection on nebivolol and imidapril in he...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a method for rapidly screening nebivolol and imidapril, which comprises the following steps: establishing an ultra-high performance liquid-ultraviolet detector (UPLC-DAD) method, and carrying out preliminary screening and quantitative detection on nebivolol and imidapril in health-care food and Chinese patent medicine for assisting in reducing blood pressure through retention time and ultraviolet spectrum information. The positive result is further confirmed by adopting ultra-high performance liquid chromatography tandem time-of-flight mass spectrometry. Compared with a traditional high performance liquid chromatography (HPLC) method, the method disclosed by the invention is shorter in time, lower in detection limit, capable of saving a mobile phase and more environmentally friendly, and is clearer and clearer than a mass spectrum method for primary screening. At present, the device is used in daily inspection work, especially in emergency detection for handling public security cases, t |
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