Fibroblast activating protein-alpha polymer-drug conjugate capable of responding to hydrolysis to cause charge upset as well as preparation method and application of polymer-drug conjugate

The invention belongs to the technical field of medicines, and particularly relates to a polymer-drug conjugate with FAP-alpha protein responding to hydrolysis to generate charge upset as well as a preparation method and application of the polymer-drug conjugate. The FAP-alpha protein polymer-drug conjugate capable of responding to hydrolysis to cause charge upset has a structure as shown in a formula (1). The FAP-alpha protein response hydrolysis induced charge upset polymer-drug conjugate provided by the invention has a very high anti-tumor curative effect and can be used for remarkably reducing the tumor volume. # imgabs0 # 本发明属于医药技术领域，具体涉及一种FAP-α蛋白响应水解致电荷翻转的聚合物-药物偶联物及其制备方法和应用。所述FAP-α蛋白响应水解致电荷翻转的聚合物-药物偶联物具有式(1)所示的结构。本发明提供的FAP-α蛋白响应水解致电荷翻转的聚合物-药物偶联物具有很高的抗肿瘤疗效，能够显著降低肿瘤体积。#imgabs0#