Optimized porcine circovirus type 2 Cap protein as well as virus-like particles and application thereof

According to the invention, the PCV2Cap protein is obtained through optimization, and then the PCV2Cap protein with relatively good solubility, immunogenicity and high expression quantity is obtained by using a yeast expression system for expression. The Cap protein constructed by the invention can...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HOU FENG, HE SUN, TANG HUIFEN, XIAO SHENGDONG, XU HENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	According to the invention, the PCV2Cap protein is obtained through optimization, and then the PCV2Cap protein with relatively good solubility, immunogenicity and high expression quantity is obtained by using a yeast expression system for expression. The Cap protein constructed by the invention can be applied to production of subunit vaccines and VLPs vaccines. 本发明通过优化获得猪圆环病毒2型Cap蛋白，再利用酵母表达系统表达，获得有较好的可溶性、免疫原性和高表达量的PCV2Cap蛋白。本发明构建的Cap蛋白可以应用于亚单位疫苗和VLPs疫苗的生产。