Modified nucleotide compound, oligonucleotide thereof and application thereof

The invention discloses a modified nucleotide compound with a structure as shown in a formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, oligonucleotides thereof, and applications of the modified nucleotide compound or the pharmaceutically acceptable salts or the stereoisomers thereof. The modified nucleotide compound provided by the invention is connected to the 5 '-terminal of oligonucleotide, so that the gene expression inhibition activity of the oligonucleotide can be improved, and the in-vivo stability of the oligonucleotide can be improved, thereby effectively improving the in-vivo druggability of the oligonucleotide. # imgabs0 # 本发明公开了一种具有式(I)所示结构的修饰核苷酸化合物或者其药学上可接受的盐或者其立体异构体，其寡聚核苷酸及其应用。将本发明提供的修饰的核苷酸化合物连接到寡核苷酸的5'-末端，可以提升寡核苷酸抑制基因表达的活性，并且可以提高寡聚核苷酸在体内的稳定性，从而有效提高其在体内的成药性。#imgabs0#