5-cyanopyrazolo [1, 5-a] pyrimidine compound and synthesis method thereof

The invention discloses a 5-cyanopyrazolo [1, 5-a] pyrimidine compound as shown in a formula III, R1 is hydrogen, chlorine, bromine, cyano, carboxyl ethyoxyl, methyl, isopropyl, tertiary butyl, cyclopropyl, isopropoxy, phenyl, 4-fluorophenyl, 4-chlorphenyl, 4-methylphenyl, 4-methoxyphenyl and 3-meth...

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Hauptverfasser: XU QILIN, CHEN NAIDONG, MA SHITANG, QU HENGTONG, SUN CHAOYUE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a 5-cyanopyrazolo [1, 5-a] pyrimidine compound as shown in a formula III, R1 is hydrogen, chlorine, bromine, cyano, carboxyl ethyoxyl, methyl, isopropyl, tertiary butyl, cyclopropyl, isopropoxy, phenyl, 4-fluorophenyl, 4-chlorphenyl, 4-methylphenyl, 4-methoxyphenyl and 3-methoxyphenyl, and R2 is hydrogen, chlorine, bromine, cyano, carboxyl ethyoxyl, methyl, isopropyl, tertiary butyl, cyclopropyl, isopropoxy, phenyl, 4-fluorophenyl, 4-chlorphenyl, 4-methylphenyl, 4-methoxyphenyl and 3-methoxyphenyl. R1 is phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 4-dimethylamino phenyl and furyl, and R2 is phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 4-dimethylamino phenyl and furyl. The invention also discloses a synthesis method of the 5-cyanopyrazolo [1, 5-a] pyrimidine compound, which comprises the following steps: mixing the 3-aminopyrazole compound, the cinnamyl aldehyde derivative, the trimethylsilyl cyanide, the catalyst, the ligand and the