Preparation method of Tirbanibulin

The invention relates to Tirbanibulin, in particular to a novel method for preparing the Tirbanibulin, and belongs to the technical field of chemical engineering. The method comprises the following steps: 1) carrying out Suzuki coupling reaction on a compound I (the chemical name is 2-(5-bromo-2-pyridine) acetonitrile) and 4-hydroxyphenylboronic acid pinacol ester to obtain an intermediate II; 2) reacting the intermediate II with 4-(2-chloroethyl) morpholine under the action of potassium carbonate to obtain an intermediate III; and 3) reacting the intermediate III under the action of sodium hydroxide to obtain the final product Tirbanibulin. The process route provided by the invention has the advantages of short route, simplicity and convenience in operation, mild conditions, high reaction yield, avoidance of use of dangerous and highly toxic products and supervision of hazardous chemicals, environmental friendliness and easiness in industrial production. # imgabs0 # 本发明涉及本发明涉及Tirbanibulin，具体涉及一种制备Tirbanibuli