Application of L-aspartic acid beta-hydroxamic acid in preparation of medicine for treating retinopathy of fundus retinopathy or premature infants

The invention provides application of L-aspartic acid beta-hydroxamic acid in preparation of a medicine for treating retinopathy of fundus retinopathy of a premature infant and belongs to the technical field of medicine. The L-aspartic acid beta-hydroxamic acid has the effects of protecting nerve re...

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Hauptverfasser: QU JIA, WU SHENGZHOU, JIANG HAIYAN, JIANG XUE, ZHOU PIANSI, PEI KAIFAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides application of L-aspartic acid beta-hydroxamic acid in preparation of a medicine for treating retinopathy of fundus retinopathy of a premature infant and belongs to the technical field of medicine. The L-aspartic acid beta-hydroxamic acid has the effects of protecting nerve retina and preventing and/or treating diabetic retinopathy or premature infant fundus retinopathy for the first time, and experiments are carried out by taking type II diabetic mice db/db mice as models and hypoxia-induced retinopathy models; it is found that the L-aspartic acid beta-hydroxamic acid can improve the functions of db/db mouse retina bipolar cells and non-long-process cells, protect nerve fiber layers and retinal ganglion cells, inhibit retinal microangiopathy and inhibit retinal angiogenesis in a hypoxia-induced retinopathy model. Therefore, the traditional Chinese medicine composition has effective prevention and treatment effects on diabetic retinopathy or fundus retinopathy of premature infants. 本发明提