Pharmaceutical composition containing vortioxetine hydrobromide and preparation method thereof

The invention provides a pharmaceutical composition containing vortioxetine hydrobromide and a preparation method of the pharmaceutical composition. The invention further relates to a hydrobromic acid vortioxetine tablet containing the pharmaceutical composition and a preparation method of the hydrobromic acid vortioxetine tablet. According to the pharmaceutical composition containing the vortioxetine hydrobromide provided by the invention, by optimizing the variety and content of each auxiliary material, the dosage of an adhesive and a lubricant is reduced, meanwhile, the drug loading capacity of a tablet is improved, and the tablet weight can be reduced in the content of drugs with the same specification. The pharmaceutical composition containing the vortioxetine hydrobromide is suitable for being subjected to wet granulation. The tablet prepared by adopting the composition and the preparation method disclosed by the invention is similar to a reference preparation in dissolution behavior in simulated stomac