Implantable depot with adjustable release profile

Implantable depots for delivery of therapeutic agents and related systems and methods are provided. In certain embodiments, an implantable depot for treating pain in a subject after a surgical procedure includes a treatment region having a first polymer and an analgesic, a first control region comprising a second polymer, and a second control region comprising a third polymer. The first and second control regions may cover the first and second surfaces of the treatment region to inhibit release of an analgesic therefrom. The depot may include one or more apertures extending through the first and second control regions and the treatment region to form one or more exposed portions. When implanted in a subject, the implantable depot can release an analgesic agent from a side surface of a treatment zone between the first surface and the second surface and from an exposed portion of the treatment zone. 提供了用于递送治疗剂的可植入贮库以及相关的系统和方法。在某些实施方案中，用于在外科手术之后治疗受试者中的疼痛的可植入贮库包括具有第一聚合物和镇痛剂的治疗区、包含第二聚合物的第一控制区、以及包含第三聚合物的第二控制区。所述第一和