Core-shell structure hydroxyapatite microsphere for skin injection filler and preparation method thereof

The invention belongs to the technical field of biomedical materials, and particularly relates to a core-shell structure hydroxyapatite microsphere for a skin injection filler and a preparation method of the core-shell structure hydroxyapatite microsphere. According to the preparation method, hydroxyapatite with high crystallinity is used as a template for the first time, hydroxyapatite microspheres with borosilicate bioactive glass as a shell are prepared through the surface tension effect, and the borosilicate bioactive glass is prepared through the biomineralization effect. The borosilicate bioactive glass coated on the outer surface of the hydroxyapatite microsphere with high crystallinity is completely converted into hydroxyapatite with low crystallinity, so that the hydroxyapatite microsphere with the core-shell structure is prepared. Wherein the crystallinity of the hydroxyapatite microspheres forming the inner core is greater than or equal to 95%; the hydroxyapatite forming the shell is formed by in-s