Composition for improving drug effect of coenzyme Q10 and application thereof

The invention provides a composition for improving the drug effect of coenzyme Q10 and application of the composition. The composition is a sustained-release microsphere constructed from chitosan microspheres including coenzyme Q10, vitamin E and active oligopeptide, the microsphere preparation process is simpler, more convenient and more efficient, the sustained-release effect is very excellent, the release rate of coenzyme Q10 in the body of a patient can be effectively controlled, and the more efficient treatment effect is achieved. Through verification, the coenzyme Q10 composition disclosed by the invention can effectively inhibit secretion of IL-6, IL-17 and TNF-alpha, relieve knee joint inflammatory injury and improve and promote damage of cartilage tissue repair. 本发明提供了一种改善辅酶Q10药效的组合物及其应用。该组合物是利用壳聚糖微球包括辅酶Q10、维生素E和活性短肽构建得到的缓释微球，该微球制备工艺流程更为简便、高效，且缓释效果也非常出色，能有效控制辅酶Q10在患者体内的释放速率，达到更为高效的治疗效果。经验证，本发明的辅酶Q10组合物能有效抑制IL-6、I L-17和TNF-ɑ的分泌，减轻膝关节炎性损伤，能够改善和促进软骨组织修复的破坏。