New Chinese medicinal component new drug Chaishao saponin soft capsule for treating PMDD liver qi depression syndrome depression subtype

The invention discloses a new Chinese medicinal component Chaishao saponin soft capsule for treating PMDD liver qi depression syndrome depression subtype. According to the invention, the Xiaoshao saponin soft capsule with stable quality is prepared through process optimization, wherein the ratio of...

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Hauptverfasser: ZHU YUHUI, HOU JINLIANG, ZHANG HAO, WEI XIA, CHEN JINGXUAN, QIAO MINGQI, ZONG FEI, LI LINGJUN, ZHU DEHAO, WANG CHANG, CAI YAWEI, MOU XIANGYU, XIA XIAOWEN, LI YAQIONG, ZHANG YUANYUAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a new Chinese medicinal component Chaishao saponin soft capsule for treating PMDD liver qi depression syndrome depression subtype. According to the invention, the Xiaoshao saponin soft capsule with stable quality is prepared through process optimization, wherein the ratio of saikosaponin to total glucosides of paeony root is 0.05-0.075: 0.04-0.06. Pharmacological and pharmacodynamic experiment results prove that the radix paeoniae alba saponin liquid medicine can significantly improve FST/TST depression-like emotion of Kunming mice; the depression mood behavior appearance and pathological index change of two PMDD liver qi depression syndrome depression subtype model rats, namely natural screening and progestational hormone withdrawal, are remarkably improved; the pharmacological mechanism is that the contents of ALLO, P and E2 in peripheral serum of a model rat are remarkably increased, and the content of ALLO in a hippocampal brain region is increased. The invention further discloses