Micro-acid response type bionic nano vesicle as well as preparation method and application thereof

The invention provides a micro-acid response type bionic nano-vesicle as well as a preparation method and application of the micro-acid response type bionic nano-vesicle. The outer layer of the micro-acid response type bionic nano-vesicle disclosed by the invention is composed of a PD-1 biological cell membrane, and apatinib is loaded into a micro-acid response PEG-PAEs nano-particle hydrophobic core of the apatinib. The Apa-PPNP (at) mPD-1 is used as a new dosage form for combined administration of a small-molecule inhibitor and a macromolecular inhibitor, apatinib and PD-1 protein can be precisely and jointly delivered to tumor tissues, the medicine is released in response to a tumor slightly acidic environment, the treatment effects of remarkably reducing tumor growth and effectively inhibiting pulmonary metastasis are achieved, meanwhile, toxic and side effects on normal tissues are also avoided, and the application prospect is wide. The biocompatibility is relatively good. 本发明提供了一种微酸响应型仿生纳米囊泡及其制备方法与应用。本发