Online biomolecule analysis for monitoring or controlling biological processes

The present invention relates to a technical solution for monitoring or controlling a biological process by drawing a discrete fluid sample from a reactor and using a fluid manifold for on-line analysis of the sample, such as by means of a sensor, in particular based on label-free biomolecular interaction analysis. The invention relates in particular to a system for determining one or more analytes in a discrete fluid sample from a container adapted to contain a fluid, comprising: one or more sensors (5) for determining an analyte (53) in a contact volume of the fluid sample, an analysis module (65) for analyzing the analyte (53) in the contact volume of the fluid sample, the present invention relates to an analysis system (10) comprising a container (20) comprising at least one main sampling line fluidly connected to the container and one or more pumps fluidly connected to the one or more main sampling lines and adapted to selectively pump fluid from the main sampling line out of the container, at least one