Pharmaceutical preparation containing tacrolimus, preparation method and application thereof

The present invention relates to long-acting injectable formulations based on a combination of biodegradable poly (D, L-lactide-co-glycolide) microparticles comprising different PLGA polymers and tacrolimus. It also relates to a process for the preparation of the microparticles and the use thereof....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KARAVAS EVANGELOS, BRIERDES, VIRGINIA, CARLEZZI, ALESSANDRO, CARRANZI LUIGI, CHATIDDU SUREYASUBRAMANIAN, LEMONAKIS, NIKOLAOS, KATSENIS, ARISTOTELIS, KOTI, KIRAN, KOUTRIS EFSTRATIOS, PAPADAKI, ARAVIND
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to long-acting injectable formulations based on a combination of biodegradable poly (D, L-lactide-co-glycolide) microparticles comprising different PLGA polymers and tacrolimus. It also relates to a process for the preparation of the microparticles and the use thereof. 本发明涉及长效可注射制剂，其基于包含不同PLGA聚合物的可生物降解聚(D,L-丙交酯-共-乙交酯)微粒与他克莫司的组合。其还涉及微粒的制备方法及其用途。