Application of miR-139-3p in screening or preparing skin melanoma treatment medicine

The invention discloses an application of miR-139-3p (micro Ribonucleic Acid-139-3p) in screening or preparing a medicine for treating skin melanoma. According to the invention, the expression of miR-139-3p is up-regulated by adopting a miRNA simulant, miR-NC is taken as a contrast, the miR-139-3p simulant and the contrast miR-NC are respectively transfected to a skin melanoma A375 cell line by applying a lipofectamine 2000 transfection reagent, then screening is carried out, the A375 cell line with stable and high expression and normal expression of miR-139-3p is obtained, in-vitro culture is carried out, and the miR-139-3p is obtained. And observing the change conditions of proliferation and migration invasion ability of the A375 cell line under the two conditions. The result shows that the miR-139-3p simulant can inhibit the proliferation and migration invasion ability (Plt, 0.05) of the A375 cell line in vitro, and the high expression of the miR-139-3p can obviously inhibit the malignancy degree (Plt, 0.0