Method for improving glutamic acid conversion rate by feedback regulation

The invention belongs to the technical field of biological fermentation, and discloses a method for improving the glutamic acid conversion rate by feedback regulation, which is based on pH feedback feed regulation, takes glucose as a carbon source, takes ammonia water as an inorganic nitrogen source...

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Hauptverfasser: LI LIANDA, WU XUELEI, ZHAO JIE, LI GUANGYU, WU SONGMIN, LI DEHENG, WANG XIAOPING, BAI HONGBING, WANG TING, ZHAO LANKUN, SUN QINBO, ZHANG TINGTING, LIU SHIZHOU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological fermentation, and discloses a method for improving the glutamic acid conversion rate by feedback regulation, which is based on pH feedback feed regulation, takes glucose as a carbon source, takes ammonia water as an inorganic nitrogen source and a pH regulator, effectively controls the glucose concentration in fermentation liquor, is beneficial to consumption and utilization of glucose by strains, and improves the glutamic acid conversion rate. Meanwhile, the glucose concentration has a certain influence on lactic acid generation, so that the concentration of fermentation byproducts mainly comprising lactic acid is reduced, and the conversion rate of glucose can be increased. 本发明属于生物发酵技术领域,公开了利用反馈调节提高谷氨酸转化率的方法,本发明方法基于PH反馈补料调节,以葡萄糖为碳源、以氨水为无机氮源和pH调节剂,有效控制发酵液中葡萄糖浓度,有利于菌种对葡萄糖的消耗利用,同时利用葡萄糖浓度对乳酸生成有一定影响,故以乳酸为主的发酵副产物浓度下降,可以提高葡萄糖的转化率。