Temperature-sensitive self-healing supramolecular hybrid hydrogel and preparation method thereof

The invention belongs to the field of biomedical hydrogel, and discloses temperature-sensitive self-healing supramolecular hydrogel and a preparation method thereof. The method comprises the following steps: taking a temperature-sensitive gelatin supramolecular polymer and oxidized hyaluronic acid as a matrix, and constructing the temperature-responsive gelatin/hyaluronic acid supramolecular hydrogel of a bionic extracellular matrix component based on a hydrophobic self-assembled stable quadruple hydrogen bond and Schiff base synergistic crosslinking strategy. The supramolecular hydrogel has the advantages of rapid sol-gel transition, good self-repairing performance and good mechanical toughness. The material has the advantages of convenience in use, simplicity in operation, small surgical injury, biosafety and the like, and can be applied to the fields of tissue engineering, drug delivery, cell therapy, tumor immunotherapy and the like. 本发明属于生物医用水凝胶领域，公开了一种温敏自愈合超分子水凝胶及其制备方法。所述方法：以温敏明胶超分子聚合物和氧化透明质酸为基质，基于疏水自组装