Triple aromatic ring compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses a teraromatic ring compound as well as a preparation method, a pharmaceutical composition and application thereof. The structure of the terphenyl aromatic ring compound is shown as a formula I, and the terphenyl aromatic ring compound further comprises a stereoisomer, a mesomer, a raceme, a prodrug, a crystal, a pharmaceutically acceptable salt or a mixture of the stereoisomer, the mesomer, the raceme, the prodrug, the crystal and the pharmaceutically acceptable salt, has PD-L1 inhibitory activity, can remarkably inhibit PD-1/PD-L1 protein-protein interaction and block a PD-1/PD-L1 signal channel, and can be used for inhibiting PD-1/PD-L1 protein-protein interaction. Therefore, the compound can be widely applied to preparation of immunomodulator drugs for preventing and/or treating tumors, infectious diseases, inflammatory diseases, autoimmune diseases and organ transplantation rejection, and meanwhile, the preparation method of the compound is beneficial to structural expansion. # img