Synthetic method for synthesizing asperizine A-type alkaloid by dimerization of domino

The invention discloses a synthetic method for synthesizing asperizineA alkaloid through dimerization of domino. The asperizineA alkaloid is used as a raw material for preparing the asperizineA alkaloid. The method comprises the following steps: carrying out reduction elimination on a compound 1 to obtain a compound 2, carrying out iodination elimination to obtain a compound 3, carrying out Suzuki coupling to obtain a compound 5, carrying out one-step domino dimerization conversion to obtain a key dimerization compound 7, and finally carrying out several-step conversion to obtain asperizineA and analogues thereof. The method provided by the invention can start from the compound 1, and provides good technical support for subsequent large-scale production and structure-function relationship research of asperizineA alkaloids. 本发明公开了一种多米诺二聚合成asperazineA类生物碱的合成方法。所述方法通过化合物1，经还原消除得化合物2，碘化消除得化合物3，再经Suzuki偶联得化合物5，而后经一步多米诺二聚转化得到关键二聚化合物7，最后分别经过几步转化得到asperazineA及其类似物。本发明所述方法能够从化合物1出发，为后续实现asperazineA类生物碱规模化生产及构效关系研究提供良好