Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof
The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is desig...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CAI JIAGENG ZHENG LEMIN SU SHENG'E ZU LINGYUN GE XIAOXIAO |
| description | The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is designed and synthesized on the basis of osteopontin with high specific expression on the surface of a foam cell, and the nano material has extremely high specificity on targeting of atherosclerotic plaque; besides, compared with polymeric nanoparticles or traditional non-degradable metal nanoparticles, the nano-particles have excellent biocompatibility and safety, FeNiPO4 has excellent acid responsiveness and is naturally degraded due to the influence of acidic conditions at unstable plaques of atherosclerosis, and a bimodal imaging mode combining photoacoustic and CT is adopted, so that the biological activity of the nano-particles is improved, and the biological activity of the nano-particles is improved. And high re |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN118022007A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN118022007A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN118022007A3</originalsourceid><addsrcrecordid>eNqNizEKwkAQRdNYiHqH8QBCEgttQzRYpbIPk-THXVh3ht0VwdNr0ANYPB48_l9m5oRb4JF7B5oefkhWPDv7wkgNWktqJKrhBPLsRYP0II70hHOzNUA58PyiO5KRkdh_UHV2-OZkECDTOltM7CI2P6-ybXO-1pcdVDpE5QEeqavbojjmZZnnh2r_z-YNLn9Amw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof</title><source>esp@cenet</source><creator>CAI JIAGENG ; ZHENG LEMIN ; SU SHENG'E ; ZU LINGYUN ; GE XIAOXIAO</creator><creatorcontrib>CAI JIAGENG ; ZHENG LEMIN ; SU SHENG'E ; ZU LINGYUN ; GE XIAOXIAO</creatorcontrib><description>The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is designed and synthesized on the basis of osteopontin with high specific expression on the surface of a foam cell, and the nano material has extremely high specificity on targeting of atherosclerotic plaque; besides, compared with polymeric nanoparticles or traditional non-degradable metal nanoparticles, the nano-particles have excellent biocompatibility and safety, FeNiPO4 has excellent acid responsiveness and is naturally degraded due to the influence of acidic conditions at unstable plaques of atherosclerosis, and a bimodal imaging mode combining photoacoustic and CT is adopted, so that the biological activity of the nano-particles is improved, and the biological activity of the nano-particles is improved. And high re</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240514&DB=EPODOC&CC=CN&NR=118022007A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240514&DB=EPODOC&CC=CN&NR=118022007A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAI JIAGENG</creatorcontrib><creatorcontrib>ZHENG LEMIN</creatorcontrib><creatorcontrib>SU SHENG'E</creatorcontrib><creatorcontrib>ZU LINGYUN</creatorcontrib><creatorcontrib>GE XIAOXIAO</creatorcontrib><title>Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof</title><description>The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is designed and synthesized on the basis of osteopontin with high specific expression on the surface of a foam cell, and the nano material has extremely high specificity on targeting of atherosclerotic plaque; besides, compared with polymeric nanoparticles or traditional non-degradable metal nanoparticles, the nano-particles have excellent biocompatibility and safety, FeNiPO4 has excellent acid responsiveness and is naturally degraded due to the influence of acidic conditions at unstable plaques of atherosclerosis, and a bimodal imaging mode combining photoacoustic and CT is adopted, so that the biological activity of the nano-particles is improved, and the biological activity of the nano-particles is improved. And high re</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizEKwkAQRdNYiHqH8QBCEgttQzRYpbIPk-THXVh3ht0VwdNr0ANYPB48_l9m5oRb4JF7B5oefkhWPDv7wkgNWktqJKrhBPLsRYP0II70hHOzNUA58PyiO5KRkdh_UHV2-OZkECDTOltM7CI2P6-ybXO-1pcdVDpE5QEeqavbojjmZZnnh2r_z-YNLn9Amw</recordid><startdate>20240514</startdate><enddate>20240514</enddate><creator>CAI JIAGENG</creator><creator>ZHENG LEMIN</creator><creator>SU SHENG'E</creator><creator>ZU LINGYUN</creator><creator>GE XIAOXIAO</creator><scope>EVB</scope></search><sort><creationdate>20240514</creationdate><title>Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof</title><author>CAI JIAGENG ; ZHENG LEMIN ; SU SHENG'E ; ZU LINGYUN ; GE XIAOXIAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118022007A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CAI JIAGENG</creatorcontrib><creatorcontrib>ZHENG LEMIN</creatorcontrib><creatorcontrib>SU SHENG'E</creatorcontrib><creatorcontrib>ZU LINGYUN</creatorcontrib><creatorcontrib>GE XIAOXIAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CAI JIAGENG</au><au>ZHENG LEMIN</au><au>SU SHENG'E</au><au>ZU LINGYUN</au><au>GE XIAOXIAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof</title><date>2024-05-14</date><risdate>2024</risdate><abstract>The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is designed and synthesized on the basis of osteopontin with high specific expression on the surface of a foam cell, and the nano material has extremely high specificity on targeting of atherosclerotic plaque; besides, compared with polymeric nanoparticles or traditional non-degradable metal nanoparticles, the nano-particles have excellent biocompatibility and safety, FeNiPO4 has excellent acid responsiveness and is naturally degraded due to the influence of acidic conditions at unstable plaques of atherosclerosis, and a bimodal imaging mode combining photoacoustic and CT is adopted, so that the biological activity of the nano-particles is improved, and the biological activity of the nano-particles is improved. And high re</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN118022007A |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T02%3A40%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CAI%20JIAGENG&rft.date=2024-05-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN118022007A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |