Degradable functionalized FeNi phosphate nanoprobe as well as preparation method and application thereof

The invention belongs to the field of medical detection, and provides a degradable functional FeNiPO4 nanoprobe as well as a preparation method and application thereof. According to the FeNiPO4 nano probe provided by the invention, a nano material modified by an osteopontin antibody (OPNAb) is designed and synthesized on the basis of osteopontin with high specific expression on the surface of a foam cell, and the nano material has extremely high specificity on targeting of atherosclerotic plaque; besides, compared with polymeric nanoparticles or traditional non-degradable metal nanoparticles, the nano-particles have excellent biocompatibility and safety, FeNiPO4 has excellent acid responsiveness and is naturally degraded due to the influence of acidic conditions at unstable plaques of atherosclerosis, and a bimodal imaging mode combining photoacoustic and CT is adopted, so that the biological activity of the nano-particles is improved, and the biological activity of the nano-particles is improved. And high re