Application of diterpenoid compound in preparation of medicine for treating cardiovascular diseases
The invention discloses application of a diterpenoid compound in preparation of a medicine for treating cardiovascular diseases, and discloses new activity data of two known compounds and application of the diterpenoid compound in remarkable inhibition of oxidative stress injury activity of SH-SY5Y...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses application of a diterpenoid compound in preparation of a medicine for treating cardiovascular diseases, and discloses new activity data of two known compounds and application of the diterpenoid compound in remarkable inhibition of oxidative stress injury activity of SH-SY5Y cells. Wherein the injury survival rates of the compound 1 and the compound 2 on SH-SY5Y cells are 84.8% and 87.4% respectively. The compounds 1 and 2 obviously inhibit the generation of Bax protein, so that the apoptosis of SH-SY5Y cells is inhibited. The two compounds have application prospects in treatment of cardiovascular diseases. The compound is separated from an egg nest fungus fermentation product, the strain is purchased in the China General Microbiological Culture Collection Center (CGMCC), and the number is CGMCC 5.1117. Meanwhile, the strain is preserved in a natural product laboratory of the Commercial College, and the strain number is No.CA20150823.
本发明公开了二萜类化合物用于制备治疗心血管疾病药物的应用,公开了2个已知化合物的新活性数据,及其用于显 |
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