Anti-respiratory syncytial virus antibody and application thereof

The invention relates to the technical field of biological medicines, provides an anti-respiratory syncytial virus antibody and an application thereof, and particularly comprises an amino acid sequence and a nucleic acid sequence for coding the whole-molecule antibody and an application of the whole...

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Bibliographische Detailangaben
Hauptverfasser:	TANG QI, HE YITING, JI MINJUN, ZHANG MINGSHUN, SHEN CHUNXIANG, ZHANG YI, CUI DAIXUN, GONG JING, FENG ZHENQING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the technical field of biological medicines, provides an anti-respiratory syncytial virus antibody and an application thereof, and particularly comprises an amino acid sequence and a nucleic acid sequence for coding the whole-molecule antibody and an application of the whole-molecule antibody. Related experiments prove that the antibody can specifically recognize the pre-F protein of the respiratory syncytial virus, the epitope is a site V region, and the antibody has a long half-life period after Fc gene engineering optimization and can effectively prevent and control infection of the RSV virus. 本申请涉及生物医药技术领域，提供一种抗呼吸道合胞病毒抗体及其应用，具体包括编码该全分子抗体的氨基酸序列及核酸序列及其应用。相关实验证实该抗体可特异性识别呼吸道合胞病毒pre-F蛋白，抗原表位为site V区域，且经过Fc基因工程优化，具有较长的半衰期，可有效地预防及控制RSV病毒的感染。