Synthesis and application of 8-hydroxyquinoline-N-oxide cobalt complex

The invention discloses synthesis and application of an 8-hydroxyquinoline-N-oxide cobalt complex, belongs to the technical field of medicines, and solves the technical problem that in the prior art, a biquinoline cobalt (II) complex is lack of research on a lung cancer cis-platinum drug-resistant cell strain, the method specifically comprises the following steps: (1) weighing an auxiliary ligand and a metal salt Co (NO3) 2.6 H2O, mixing, and carrying out ultrasonic treatment to obtain a mixed solution; the auxiliary ligand is 1, 10-phenanthroline or 4, 7-dichloro-1, 10-phenanthroline, and the auxiliary ligand is 1, 10-phenanthroline or 4, 7-dichloro-1, 10-phenanthroline; (2) adding CH3OH, CH2Cl2 and triethylamine, and carrying out a reaction; (3) after the reaction is finished, cooling; (4) adding 8-hydroxyquinoline-N-oxide into the above system, and carrying out a reaction; and (5) after the reaction is finished, cooling to obtain black blocky crystals. Research finds that YNU-2c and YNU-2d have a very good