Diterpenoid compound and application of diterpenoid compound in anti-neuroinflammation medicine

The invention discloses a diterpenoid compound and application of the diterpenoid compound in an anti-neuroinflammation medicine, and discloses new activity data of two known compounds, and application of the diterpenoid compound in remarkably promoting PC12 nerve cell axon growth activity and inhib...

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Hauptverfasser: ZHAO YANYAN, WEI JING, LI XIAN, WANG XUEJUN, ZHANG YILIN, HUI HEPING, CHEN LIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a diterpenoid compound and application of the diterpenoid compound in an anti-neuroinflammation medicine, and discloses new activity data of two known compounds, and application of the diterpenoid compound in remarkably promoting PC12 nerve cell axon growth activity and inhibiting SH-SY5Y cell oxidative stress injury activity. Wherein the axon growth promotion rate of the compound 2 to PC12 cells is 25.8%. The injury survival rate of the compound 1 to SH-SY5Y cells reaches 86.2%. The compound 1 obviously inhibits the generation of Bax protein, so that the apoptosis of SH-SY5Y cells is inhibited. The two compounds have application prospects in treatment of neuroinflammation diseases. The compound is separated from an egg nest fungus fermentation product, the strain is purchased in the China General Microbiological Culture Collection Center (CGMCC), and the number is CGMCC 5.1163. Meanwhile, the strain is preserved in a natural product laboratory of the Shangluo College, and the strain n