Anti-tumor traditional Chinese medicine composition, preparation thereof and application of anti-tumor traditional Chinese medicine composition in preparation of PD-1 inhibitor synergist

The invention discloses an anti-tumor traditional Chinese medicine composition, a preparation method thereof and application of the anti-tumor traditional Chinese medicine composition in preparation of a synergist of a PD-1 inhibitor. The anti-tumor traditional Chinese medicine composition comprises ginsenoside Rg1 and atractylenolide-I, wherein the mass ratio of the ginsenoside Rg1 to the atractylenolide-I is (4: 1)-(1: 4). The composition may also include a drug carrier and a surface modification material. In the composition, ginsenoside Rg1 can regulate normalization of a cholesterol metabolism MVA pathway of the dendritic cells and enhance the antigen presentation capability of the dendritic cells; the atractylenolide I can enhance the immunoproteasome activity of tumor cells so as to up-regulate the MHC-I expression of the tumor cells. The drug carrier can efficiently carry the anti-tumor traditional Chinese medicine composition together, and the surface modification material can realize in-vivo Ly6C + m