PH responsive polypeptide-curcumin co-assembled hydrogel as well as preparation method and application thereof

PH responsive polypeptide-curcumin co-assembled hydrogel as well as preparation method and application thereof

The invention belongs to the technical field of nano biological materials, and discloses pH responsive polypeptide-curcumin co-assembled hydrogel as well as a preparation method and application thereof. The polypeptide is Nap-FFKKK, that is, the amino acid sequence of the polypeptide is FFKKK, and t...

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Hauptverfasser: ZHANG XIAOLI, WANG MENGYAO, ZHANG JUNJIE, WANG YU, PU GUOJUAN
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Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ZHANG XIAOLI
WANG MENGYAO
ZHANG JUNJIE
WANG YU
PU GUOJUAN
description The invention belongs to the technical field of nano biological materials, and discloses pH responsive polypeptide-curcumin co-assembled hydrogel as well as a preparation method and application thereof. The polypeptide is Nap-FFKKK, that is, the amino acid sequence of the polypeptide is FFKKK, and the N end of the amino acid sequence is connected with a Nap end-capping group. The preparation method comprises the following steps: dissolving polypeptide Nap-FFKKK in a PBS (Phosphate Buffer Solution) with the pH value of 7.0-8.0, then adding a curcumin/DMSO (Dimethylsulfoxide) solution, then adding a NaOH aqueous solution to adjust the pH value of the system to 7.8-8.0, and standing at room temperature until hydrogel is formed, so as to obtain the pH responsive polypeptide-curcumin co-assembled hydrogel. The invention also discloses application of the pH responsive polypeptide-curcumin co-assembled hydrogel in preparation of drugs for treating drug-resistant bacteria infectious diseases. The polypeptide-curcumin
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PH responsive polypeptide-curcumin co-assembled hydrogel as well as preparation method and application thereof
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