Method for detecting activity of anti-CD22 monoclonal antibody and application thereof
The invention discloses a method for detecting the activity of an anti-CD22 monoclonal antibody, which comprises the following steps: co-incubating a to-be-detected anti-CD22 monoclonal antibody and RAMOS cells, detecting the concentration of the endocytosis to-be-detected anti-CD22 monoclonal antib...
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| creator | HUANG JIANLE CHONG CHI HO |
| description | The invention discloses a method for detecting the activity of an anti-CD22 monoclonal antibody, which comprises the following steps: co-incubating a to-be-detected anti-CD22 monoclonal antibody and RAMOS cells, detecting the concentration of the endocytosis to-be-detected anti-CD22 monoclonal antibody, comparing the concentration of the endocytosis to-be-detected anti-CD22 monoclonal antibody with the original concentration of the to-be-detected anti-CD22 monoclonal antibody, and determining the activity of the to-be-detected anti-CD22 monoclonal antibody. The activity of the anti-CD22 monoclonal antibody to be detected is obtained. Aiming at the unique action mechanism of the anti-CD22 antibody, the invention provides a specific cell-based activity detection method which is suitable for quality control of anti-CD22 monoclonal antibodies such as SM03, SM06 and the like; the activity detection of the anti-CD22 monoclonal antibody is realized by measuring the internalization rate of the antibody combined with |
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The activity of the anti-CD22 monoclonal antibody to be detected is obtained. Aiming at the unique action mechanism of the anti-CD22 antibody, the invention provides a specific cell-based activity detection method which is suitable for quality control of anti-CD22 monoclonal antibodies such as SM03, SM06 and the like; the activity detection of the anti-CD22 monoclonal antibody is realized by measuring the internalization rate of the antibody combined with</description><language>chi ; eng</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240507&DB=EPODOC&CC=CN&NR=117990911A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240507&DB=EPODOC&CC=CN&NR=117990911A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUANG JIANLE</creatorcontrib><creatorcontrib>CHONG CHI HO</creatorcontrib><title>Method for detecting activity of anti-CD22 monoclonal antibody and application thereof</title><description>The invention discloses a method for detecting the activity of an anti-CD22 monoclonal antibody, which comprises the following steps: co-incubating a to-be-detected anti-CD22 monoclonal antibody and RAMOS cells, detecting the concentration of the endocytosis to-be-detected anti-CD22 monoclonal antibody, comparing the concentration of the endocytosis to-be-detected anti-CD22 monoclonal antibody with the original concentration of the to-be-detected anti-CD22 monoclonal antibody, and determining the activity of the to-be-detected anti-CD22 monoclonal antibody. The activity of the anti-CD22 monoclonal antibody to be detected is obtained. 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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | Method for detecting activity of anti-CD22 monoclonal antibody and application thereof |
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