Procoagulant high-adhesion hydrogel as well as preparation method and application thereof

The invention provides a procoagulant high-adhesion hydrogel as well as a preparation method and application thereof, and the procoagulant high-adhesion hydrogel is prepared by the following steps: dissolving dopamine-polypeptide-azide-oxidized hyaluronic acid (PD-OHA-azide) and dopamine-polypeptide-alkyne-oxidized hyaluronic acid (PD-OHA-alkyne) in deionized water containing a catalyst at room temperature, and standing and crosslinking at room temperature to obtain the hydrogel. The hydrogel provided by the invention is obtained through azide-alkyne click reaction, has higher yield and selectivity under mild conditions, not only has excellent adhesion, hemostatic effect and mechanical property, but also has biodegradability and high biocompatibility, and can be greatly applied to the medical field of closed bleeding wounds. 本申请提供一种促凝血高粘附水凝胶及其制备方法和应用，包括将多巴胺-多肽-叠氮-氧化透明质酸(PD-OHA-azide)和多巴胺-多肽-炔-氧化透明质酸(PD-OHA-alkyne)在室温下溶于含有催化剂的去离子水中，在室温下静置交联得的水凝胶。本申请的水凝胶通过叠氮-炔的点击反应得到，温和条件下具有较高收率和选择性，该水凝胶不仅且具有优异的粘附性、止血效果和力学性能，并具