Nanometer antibody specifically binding to CD39 and application thereof

The invention provides a nano antibody which is specifically bound with CD39 and can inhibit the enzyme activity of soluble CD39 and the enzyme activity of CD39 on the surface of a cell membrane, a preparation method, a composition and the like of the nano antibody, the protein binding activity of t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HONG PO, DONG JIEXIAN, BAI GUIRONG, LI ZONGYAN, HUANG LIMEI, ZHOU XIANGSHAN, HUANG QING, CHEN CUIJUAN, WANG MENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention provides a nano antibody which is specifically bound with CD39 and can inhibit the enzyme activity of soluble CD39 and the enzyme activity of CD39 on the surface of a cell membrane, a preparation method, a composition and the like of the nano antibody, the protein binding activity of the nano antibody is equivalent to that of a nano antibody R-Ye-19 (1)-037 and a nano antibody R-Ye-19 (1)-046 in the patent WO2023186121A1, the maximum enzyme activity inhibition rate of the protein level of the nano antibody is superior to that of the nano antibody R-Ye-19 (1)-037 and the nano antibody R-Ye-19 (1)-046 in the patent WO2023186121A1, and the nano antibody can be used for preparing the nano antibody. The maximum enzyme activity inhibition rate of the CD39 at the cellular level and the IC50 are superior to those of the anti-CD39 nano antibody R-Ye-19 (1)-037 and the anti-CD39 nano antibody R-Ye-19 (1)-046 in the patent WO2023186121A1. 本公开提供了一种特异性结合CD39，并可抑制可溶性CD39酶活及细胞膜表面CD39酶活的纳米抗体、其制备方法、组合物等，其蛋白结合活性与