Synthetic method of canagliptide

The invention relates to the technical field of polypeptide drug synthesis, in particular to a synthesis method of canagliptin. The HPLC (High Performance Liquid Chromatography) purity of the canagliflozin prepared by the synthesis method provided by the invention reaches 99% or above, the content of a single impurity is lower than 0.1%, the product quality and the total yield are improved, and the whole synthesis process is simple to operate and low in comprehensive synthesis cost, is very suitable for industrial production of polypeptide bulk drugs, and has wide practical value and application prospect. 本发明涉及多肽药物合成技术领域，尤其涉及一种卡格列肽的合成方法。本发明中提供的合成方法所制得的卡格列肽，其HPLC纯度达99％以上，单个杂质低于0.1％，不仅提高了产品质量和总收率，而且整个合成工艺操作简单，综合合成成本低，非常适合多肽原料药的工业化生产，具有广泛的实用价值和应用前景。