Spiro compound as well as preparation method and application thereof

The invention relates to a spiro compound as well as a preparation method and application thereof. The spiro compound is shown as a formula I, has 3CL protease inhibitory activity, can effectively inhibit RNA virus replication which depends on 3CL protease to perform protein complex hydrolysis, and...

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Bibliographische Detailangaben
Hauptverfasser:	TIAN, GUANGHUI, ZHU WEILIANG, LI ZHIQIANG, ZHANG YAN, JIANG, HUALIANG, XIAO GENGFU, JIANG XIANGRUI, SHEN, JINGSHAN, ZHANG LEIRA, XU ZHIJIAN, ZHANG QIUMENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a spiro compound as well as a preparation method and application thereof. The spiro compound is shown as a formula I, has 3CL protease inhibitory activity, can effectively inhibit RNA virus replication which depends on 3CL protease to perform protein complex hydrolysis, and is further used for preventing or treating related diseases. # imgabs0 # 本发明涉及一类螺环化合物及其制备方法和用途。所述螺环化合物如式I所示，具有3CL蛋白酶抑制活性，可有效抑制依赖3CL蛋白酶进行蛋白复合物水解的RNA病毒复制，进而用于相关疾病的预防或治疗。#imgabs0#