Near-infrared light-triggered degradable dual-response nano drug delivery system as well as preparation method and application of near-infrared light-triggered degradable dual-response nano drug delivery system

The invention belongs to the field of pharmaceutical preparations, and relates to a near-infrared light triggered degradable dual-response nano drug delivery system as well as a preparation method and application thereof. The nano drug-loading system comprises a thermosensitive liposome, drug-loading nanoparticles are encapsulated in a hydrophilic cavity of the thermosensitive liposome, photothermal conversion molecules and thrombin response peptide are loaded on a hydrophobic layer, and platelet targeting peptide is contained on the surface of the thermosensitive liposome. The preparation method comprises the following steps: (1) preparing the drug-loaded nanoparticles; and (2) preparing the nano drug delivery system. According to the nano drug delivery system, the administration dosage of the thrombolytic drug is reduced, meanwhile, the effective concentration of the thrombolytic drug at the thrombus part is increased, serious adverse reactions such as general hemorrhage are reduced, and the safety of throm