Anti-CTLA-4 binding proteins and methods of use thereof

Provided herein are antigen binding proteins (ABPs) having binding specificity for CTLA-4 and compositions, including pharmaceutical compositions, diagnostic compositions, and kits, comprising such ABPs. Also provided are methods of making CTLA-4ABP, and methods of using CTLA-4ABP for, for example,...

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Bibliographische Detailangaben
Hauptverfasser:	JOHNSON DOUGLAS SCOTT, ADLER ADAM S, LIN YONGWEN, MIZRAHI ROBERT A, ISENHUGH MARK, STONE, EDWARD, L
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are antigen binding proteins (ABPs) having binding specificity for CTLA-4 and compositions, including pharmaceutical compositions, diagnostic compositions, and kits, comprising such ABPs. Also provided are methods of making CTLA-4ABP, and methods of using CTLA-4ABP for, for example, therapeutic purposes, such as treatment of cancer, diagnostic purposes, and research purposes. 本文提供了对CTLA-4具有结合特异性的抗原结合蛋白(ABP)和包含此类ABP的组合物，包括药物组合物、诊断组合物和试剂盒。还提供了制备CTLA-4ABP的方法，以及将CTLA-4ABP用于例如治疗目的诸如治疗癌症、诊断目的和研究目的的方法。