Blood purifying apparatus

提供除去低分子蛋白质等血液处理能力强，而且由透析液侧流入内毒素少的血液净化器。本发明的血液净化器，通过高分子物质透过试验得到的溶质透过系数α值除以水透过性能Lp值得到的值α/Lp为6×10#+[-7]以上3×10#+[-5]以下，其中，Lp是指式(2)定义的值，其单位为ml/Hr/mmHg/m#+[2]：Lp＝V×60÷ΔP÷膜面积 (2)式(2)中，V表示过滤开始5分钟后1分钟内由血液侧出口流出的聚乙烯吡咯烷酮溶液的流量，其单位为ml/分；ΔP是指重均分子量为35000的聚乙烯吡咯烷酮的20ppm水溶液通过全过滤以100ml/分的流速，由血液净化器的透析液侧流向血液侧，过滤开始至5分钟后透析液侧压力与血液侧压力的差，其单位为mmHg；膜面积是指血液净化器的有效内膜面积，其单位为m#+[2]；α是指式(3)定义的值：α＝透过率÷Lp÷ΔP (3)式(3)中，透过率(％)＝100×血液侧出口浓度÷原液浓度。 A blood purifying apparatus having excellent purification performance (elimination of low molecular proteins, etc.) and being contaminated with little endotoxins flowing from the dialyzate side. Attention was paid to the solute permeability coefficient alpha and water permeability performance Lp of blood purifying apparatus and the relation between alpha and Lp has been examined. As a result, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the value alpha /Lp to 6x10 or above, or regulating alpha within a range of 8x10 to 1.5x10, and the value alpha x Lp to 2.4x10 or less. Also, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the invasion ratio which is obtained by the polymer invasion test to 10% or less. The blood purifying apparatus has an excellent blood purifying performance expressed typically by the elimination ratio of low-molecular weight proteins and is substantially free from invasion of endotoxins from the dialyzate side, which makes it useful in, for example, treating patients with renal dysfunction.