GREM1 as biomarker for predicting metastasis or poor prognosis of non-small cell lung cancer and application of GREM1

The invention discloses GREM1 as a biomarker for predicting non-small cell lung cancer metastasis or poor prognosis and application of the GREM1, and relates to the technical field of biological medicine. The biomarker is a GREM1 gene. The invention also provides application of the reagent for detecting the expression quantity of the GREM1 gene in the lung tissue in preparation of the following products (1) or (2): (1) a product for predicting non-small cell lung cancer metastasis; and (2) a product for predicting poor prognosis of lung adenocarcinoma. The research finds that the GREM1 is highly expressed in non-small cell lung cancer tissues, and the high expression of the GREM1 is closely related to non-small cell lung cancer metastasis and poor prognosis, so that the GREM1 can be used as a biomarker for predicting non-small cell lung cancer metastasis or poor prognosis. 本发明公开了GREM1作为预测非小细胞肺癌转移或不良预后的生物标志物及其应用，涉及生物医药技术领域。所述生物标志物为GREM1基因。本发明还提供检测GREM1基因在肺组织中表达量的试剂在制备以下(1)或(2)所述的产品中的应用：(1)预测非小细胞肺癌转移的产品；(2)预测肺腺