Application of pp '-DDE and homologues thereof in preparation of medicines for treating osteoporosis

According to the application of the pp '-DDE in preparation of the medicine for treating the osteoporosis, the pp'-DDE and homologues (DDT, op '-DDT, pp'-DDD and the like) of the pp '-DDE are taken as effective components, and formation of mineralized nodules of osteoblasts is promoted by improving expression of molecules such as Ocn, Alpl and Sp7 in the osteoblasts, so that the thickness of cortical bones or femur is increased, the symptom of the osteoporosis is improved, and the purpose of treating the osteoporosis is achieved. 本发明提供pp'-DDE在制备治疗骨质疏松药物中的应用，以pp'-DDE及其同系物(DDT；op'-DDT；pp'-DDD等)为药效成分通过提高成骨细胞中的Ocn、Alpl、Sp7等分子的表达，促进成骨细胞矿化结节的形成，从而提高皮质骨或者股骨的厚度，改善骨质疏松的症状，达到治疗骨质疏松的目的。