Iterative image reconstruction

Systems and methods are disclosed for performing operations including accessing a current structure estimate of a region of interest; generating a first simulated X-ray measurement based on the current structure estimate of the region of interest; receiving a first real X-ray measurement; and generating an update to a current structure estimate of the region of interest from the first simulated X-ray measurement and the first real X-ray measurement, the update being generated invariably with respect to the current structure estimate. 公开了用于执行操作的系统和方法，操作包括：访问感兴趣区域的当前结构估计；基于感兴趣区域的当前结构估计来生成第一模拟X射线测量；接收第一真实X射线测量；以及根据第一模拟X射线测量和第一真实X射线测量来生成对感兴趣区域的当前结构估计的更新，更新是关于当前结构估计不变地生成的。