Pyridine derivative and application thereof

The invention relates to a pyridine derivative and application thereof, the compound has an obvious inhibition effect on KRAS and PI3K protein activity, can be used as a KRAS and/or PI3K protein inhibitor, can be used for preparing medicines for treating diseases such as cancers mediated by KRAS and...

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Bibliographische Detailangaben
Hauptverfasser:	WANG HAIBO, LIU MINGDENG, XIONG YONG, QIANG XIAOMING, DING ZHAO, LIU KE, CHEN SHOUJUN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a pyridine derivative and application thereof, the compound has an obvious inhibition effect on KRAS and PI3K protein activity, can be used as a KRAS and/or PI3K protein inhibitor, can be used for preparing medicines for treating diseases such as cancers mediated by KRAS and PI3K protein, has an extremely strong inhibition effect on KRAS G12C inhibitors such as AMG-510 drug-resistant cancer cells, and has a wide application prospect. 一种吡啶类衍生物及其用途，该类化合物对KRAS和PI3K蛋白活性具有明显的抑制作用，可作为KRAS和/或PI3K蛋白抑制剂，可用于制备治疗由KRAS、PI3K蛋白介导的癌症等疾病的药物，且所述化合物对于KRAS G12C抑制剂如AMG-510耐药癌细胞具有极强的抑制作用，具有广阔的应用前景。