Spirolactone tablet and preparation method thereof

The invention relates to a spirolactone tablet and a preparation method thereof, and the spirolactone tablet comprises the following components in percentage by weight: 10% of spirolactone, 5-8% of PEG6000, 10-15% of starch, 0.5-1.5% of lubricant and the balance of filler. The preparation method com...

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Bibliographische Detailangaben
Hauptverfasser: FU YAFANG, FAN LONGLONG, YANG XIAOLIN, KANG JIANDANG, ZHANG BAOLEI, LI SHANG, ZHOU JING, LIU SHENGJIE, YANG ZHONGYI, WEN QINGYUE, DING LONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a spirolactone tablet and a preparation method thereof, and the spirolactone tablet comprises the following components in percentage by weight: 10% of spirolactone, 5-8% of PEG6000, 10-15% of starch, 0.5-1.5% of lubricant and the balance of filler. The preparation method comprises the following steps: performing gelatinization reaction on starch and PEG (Polyethylene Glycol), mixing with other raw materials, mixing in a fluidized bed, granulating, coating and tabletting. The characteristic that PDG6000 can be melted at the temperature of 55-60 DEG C is utilized, PDG6000 is used as an adhesive, a fluidized bed granulation method is adopted to prepare the spironolactone tablet, water does not need to be added in the whole preparation process, and the whole process is simple, convenient to operate and low in cost; meanwhile, the PEG6000 has excellent hydrophilicity, so that the surface smoothness of the medicine particles can be improved, the friction among the medicine particles is redu