Bifunctional antibody combined with coronavirus as well as preparation method and application of bifunctional antibody

The invention discloses a bifunctional fusion protein combined with coronavirus, binding regions at two ends of the bifunctional fusion protein are respectively combined with different epitopes of a Spike protein, and the bifunctional fusion protein simultaneously has the functions of resisting SARS...

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Bibliographische Detailangaben
Hauptverfasser:	SHAO SHUNRU, GUO QINGCHENG, GONG HUI, ZHANG XUNMIN, ZHANG DAPENG, TAO JING, LI WEI, WANG HAO, LI JIYANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a bifunctional fusion protein combined with coronavirus, binding regions at two ends of the bifunctional fusion protein are respectively combined with different epitopes of a Spike protein, and the bifunctional fusion protein simultaneously has the functions of resisting SARS-CoV and SARS-CoV-2 and the function of combining ACE2. The bifunctional fusion protein combined with coronavirus provided by the invention has the capability of treating virus infected cells, and also has the effects of resisting viruses, reducing lung inflammation, reducing cytokine storm and treating lung injury. 本发明公开了一种结合冠状病毒的双功能融合蛋白，其两端结合区域分别结合冠状病毒S蛋白(Spike蛋白)的不同表位，同时具有抗SARS-CoV及抗SARS-CoV-2的功能，及结合ACE2的功能。本发明所提供的结合冠状病毒的双功能融合蛋白，具有治疗病毒感染细胞的能力，同时还具有抗病毒及降低肺部炎症、降低细胞因子风暴、治疗肺部损伤的作用。