Triazole derivative capable of inhibiting activity of liver cancer cells as well as preparation method and application of triazole derivative

The invention discloses a triazole derivative capable of inhibiting activity of liver cancer cells as well as a preparation method and application of the triazole derivative. The structural formula of the derivative is # imgabs0 # imgabs1 #, wherein n is 0, 1, 2 or 3; r1, R2, R3, R4 and R5 are one or more of H, halogen, trifluoromethyl, ethyl, phenyl, hydroxyl, cyano, nitro, aromatic ring and the like. According to the preparation method of the compound, the purity of the product can be improved, the triazole derivative with the activity of inhibiting liver cancer cells is applied to preparation of anti-alcoholic hepatic fibrosis drugs or anti-tumor drugs, and tumors are liver cancer cells HepG2 and HUH7 and lung cancer cell lines NCI-H1299, NCI-H1437 and A549. 本发明公开具有抑制肝癌细胞活性的三唑类衍生物及制备方法和应用，衍生物结构式为：#imgabs0##imgabs1#其中n为0，1，2或3；R1，R2，R3，R4和R5为H、卤素、三氟甲基、乙基、苯基、羟基、氰基、硝基、芳环等一种或几种。上述化合物的制备方法可以提高产物纯度，具有抑制肝癌细胞活性的三唑类衍生物应用在制备抗酒精性肝纤维化药物或抗肿瘤药物中，所述肿瘤为肝癌细胞HepG2、HUH7、肺癌细胞系NCI-H1299、NCI-H1437、A549。