Production process of 2-propylthio-4, 6-dihydroxypyrimidine
The invention discloses a production process of 2-propylthio-4, 6-dihydroxypyrimidine, which comprises the following steps: adding a sodium methoxide methanol solution and methanol into a reaction kettle, stirring, adding thiourea in batches, heating, dropwise adding dimethyl malonate or diethyl mal...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a production process of 2-propylthio-4, 6-dihydroxypyrimidine, which comprises the following steps: adding a sodium methoxide methanol solution and methanol into a reaction kettle, stirring, adding thiourea in batches, heating, dropwise adding dimethyl malonate or diethyl malonate, and preserving heat after dropwise adding; carrying out reduced pressure distillation to remove a solvent, adding water, controlling the temperature, dropwise adding liquid caustic soda, stirring after dropwise adding, dropwise adding n-propyl bromide or tetrabutylammonium iodide and n-propane chloride, and carrying out heat preservation; and dropwise adding acid, centrifuging and drying to obtain the product. A continuous feeding process is adopted, after dimethyl malonate and thiourea react in a sodium methoxide methanol solution to obtain an intermediate state, after-treatment is not carried out, condensation reaction is directly carried out to obtain 2-propylthio-4, 6-dihydroxypyrimidine, the purity is h |
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