Application of combination of IL-12 and temozolomide in preparation of drug for treating brain tumor and composition

The invention provides application of combination of IL-12 and temozolomide in preparation of a drug for treating brain tumors and a composition, and belongs to the field of biological medicines. According to the application, the mass dosage ratio of IL-12 to temozolomide in the medicine for treating the brain tumor is (1-3): 2,000; compared with the prior art, the application of the combination of the IL-12 and the temozolomide in preparation of the drug for treating the brain tumor has the advantages that a good tumor treatment effect can be shown under the condition of low dosage of the IL-12 and the temozolomide, and the toxicity caused by traditional high-dosage medication can be effectively reduced; for a temozolomide non-sensitive cell strain, IL-12 can reverse the drug resistance of temozolomide and improve the sensitivity of tumor to temozolomide, so that the antitumor effectiveness is enhanced. 本发明提供了IL-12和替莫唑胺联用在制备治疗脑肿瘤药物的用途及组合物，属于生物医药领域；所述用途中治疗脑肿瘤的药物中IL-12与替莫唑胺的质量用量比为1-3：2000；相比于现有技术，本发明提供的IL-12和替