Application of alkyl quaternary ammonium salt compound in preparation of anti-cancer drugs
The invention belongs to the field of medicine, and particularly relates to application of dodecyl quaternary ammonium salt compounds in preparation of anti-cancer drugs. It is found that the alkyl quaternary ammonium salt compounds shown in the formulas (I)-(XII) can specifically inhibit proliferat...
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Zusammenfassung: | The invention belongs to the field of medicine, and particularly relates to application of dodecyl quaternary ammonium salt compounds in preparation of anti-cancer drugs. It is found that the alkyl quaternary ammonium salt compounds shown in the formulas (I)-(XII) can specifically inhibit proliferation of human colorectal cancer cells, human cervical cancer cells, human gastric cancer cells, human liver cancer cells, human breast cancer cells and human ovarian cancer cells respectively, the effect is better than that of 5-Fu, and the alkyl quaternary ammonium salt compounds can be used for preparing anti-tumor drugs and have good application prospects.
本发明属于医药领域,具体涉及十二种烷基季铵盐类化合物在制备抗癌药物中的应用。本发明发现,式(Ⅰ)-(Ⅻ)所示的烷基季铵盐类化合物能够分别特异性的抑制人结直肠癌细胞、人宫颈癌细胞、人胃癌细胞、人肝癌细胞、人乳腺癌细胞、人卵巢癌细胞的增殖,且效果优于5-Fu,可用于抗肿瘤药物的制备,具有良好的应用前景。 |
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