PH response type nano drug-loaded micelle as well as preparation method and application thereof

The invention discloses a pH response type nano drug-loaded micelle as well as a preparation method and application thereof, and belongs to the technical field of nano drugs, the preparation method comprises the following steps: reacting maleimide polyethylene glycol hydroxyl with epsilon-caprolactone to prepare MAL-PEG-PCL (Maleic Anhydride-Polyethylene Glycol-Polycaprolactone); the MAL-PEG-PCL is subjected to halogenation, halogen in the halogenated MAL-PEG-PCL is replaced with PEDA, and MAL-PEG-PCL-PEDA is prepared; the preparation method comprises the following steps: preparing H2N-T-PEG-PCL-PEDA by adopting MAL-PEG-PCL-PEDA; the preparation method comprises the following steps: grafting a gland receptor activating agent on H2N-T-PEG (Polyethylene Glycol)-PCL (Polyethylene Diamine)-PEDA (Poly Ethylene Diamine), so as to prepare BBB-T-PEG And mixing the BBB-T-PEG-PCL-PEDA with a therapeutic drug, so as to prepare the nano drug-loaded micelle. The nano drug-loaded micelle can effectively solve the problems